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Oligonucleotides, or are useful for administration directly to patientsįor antiviral therapy or prophylaxis.

Useful as intermediates for the preparation of antiviral compounds or With the proviso that when a is 2 and X is N, (a) two R groupsĬan be taken together to form a carbocycle or oxygen-containing heterocycle, Is -H or C1-C8 alkyl, provided that at least one R is not H and a is 1 or 2, R3 is C1-C12 alkyl X is N or O R is independently H, C1-C12 alkyl, aryl,Īlkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl,Īrylalkenyl or arylalkyl which is unsubstituted or is substituted with halo,Īzido, nitro, -O-, -N-, -NR4-, -N(R4)2- or OR3, R4 independently Unsubstituted or is substituted with halo, azido, nitro or OR3 in which Is H, C1-C12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl,Īlkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is Phosphonomethoxy nucleotide analogs with carbonates and/orĬarbamates having the structure -OC(R2)2OC(O)X(R)a, wherein R2 independently Novel compounds are provided that comprise esters of antiviral